The contrast agent microbubbles reached by an ultrasound beam powerful enough explode producing a strong and very short backscatter echo which is read by the unit as a doppler signal and results in a color pixel where the individual microbubble exploded. With the introduction of microbubble contrast agents diagnostic ultrasound has entered a new era that allows the dynamic detection of tissue flow of both the macro and microvasculature underpinning this development is the fact that gases are compressible and thus the microbubbles expand and contr . Contrast enhanced ultrasound ceus is the application of ultrasound contrast medium to traditional medical sonography ultrasound contrast agents rely on the different ways in which sound waves are reflected from interfaces between substances this may be the surface of a small air bubble or a more complex structure. The recent development of site targeted ultrasound contrast agents has expanded the role of ultrasound even further into molecular imaging applications molecular imaging with ultrasound can be used to visualize the expression of intravascular receptors and to assess their local concentration over time and or during therapeutic treatment
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