Large randomized clinical trials of treatments with blood pressure lowering drug regimens have a long history that is usually dated from the veterans administration since renamed the department of veterans affairs va cooperative study on antihypertensive drugs which reported results from 1967 1972. The national heart lung and blood institute assembled an ad hoc working group to evaluate opportunities for new major clinical trials in the field of hypertension the mandate of this working group was to consider the possible designs of major randomized clinical trials focused on clinical outcomes that might merit significant investment by the . Portopulmonary hypertension treatment with macitentan a randomized clinical trial rochester mn 24 week study to evaluate the efficacy and safety of macitentan for the treatment of portopulmonary hypertension help hy health education and sleep program in hypertension rochester mn. Download citation clinical trials in hypertension to the editor in the anglo scandinavian cardiac outcomes trial ascot1 there were more deaths cardiovascular events and strokes in